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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD4
All Species:
5.15
Human Site:
T505
Identified Species:
11.33
UniProt:
Q9NXE4
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXE4
NP_060221.2
827
93352
T505
H
R
Q
H
R
L
F
T
A
P
T
F
T
G
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543560
827
93189
T505
H
R
Q
H
R
L
F
T
A
P
T
F
T
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZPR5
823
93257
R501
I
I
P
H
R
Q
H
R
L
F
T
V
T
T
S
Rat
Rattus norvegicus
NP_001161278
823
93261
R501
I
I
P
H
R
Q
H
R
L
F
T
A
T
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509989
509
58534
S195
L
T
P
S
F
G
G
S
Y
L
S
S
W
P
P
Chicken
Gallus gallus
XP_415236
827
94779
M506
H
R
Q
H
R
L
F
M
T
P
T
L
G
G
S
Frog
Xenopus laevis
Q5XHG1
824
93777
L505
H
R
Q
H
R
L
L
L
T
P
N
L
G
G
S
Zebra Danio
Brachydanio rerio
Q6PFJ7
791
89972
L471
Q
R
H
N
R
V
F
L
T
P
S
H
G
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650124
767
86929
D450
F
S
Q
H
D
L
V
D
K
L
Q
R
F
E
A
Honey Bee
Apis mellifera
XP_623882
744
86631
N430
D
D
V
G
L
S
R
N
R
C
V
S
T
N
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784153
874
98584
N540
G
G
G
G
L
N
A
N
P
S
F
M
S
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
92
N.A.
89.8
90.3
N.A.
46.1
74.9
66.2
60.5
N.A.
24.2
29.5
N.A.
31
Protein Similarity:
100
N.A.
N.A.
94.5
N.A.
93.8
93.9
N.A.
51.8
83.9
77.6
71.9
N.A.
42.2
47.4
N.A.
49.2
P-Site Identity:
100
N.A.
N.A.
100
N.A.
33.3
33.3
N.A.
0
73.3
60
40
N.A.
20
6.6
N.A.
6.6
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
33.3
33.3
N.A.
13.3
73.3
60
60
N.A.
26.6
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
0
19
0
0
10
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
10
10
0
0
10
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
10
0
0
0
10
0
37
0
0
19
10
19
10
0
0
% F
% Gly:
10
10
10
19
0
10
10
0
0
0
0
0
28
46
0
% G
% His:
37
0
10
64
0
0
19
0
0
0
0
10
0
0
0
% H
% Ile:
19
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
19
46
10
19
19
19
0
19
0
10
0
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
10
0
10
0
19
0
0
10
0
0
10
0
% N
% Pro:
0
0
28
0
0
0
0
0
10
46
0
0
0
10
10
% P
% Gln:
10
0
46
0
0
19
0
0
0
0
10
0
0
0
10
% Q
% Arg:
0
46
0
0
64
0
10
19
10
0
0
10
0
0
0
% R
% Ser:
0
10
0
10
0
10
0
10
0
10
19
19
10
10
73
% S
% Thr:
0
10
0
0
0
0
0
19
28
0
46
0
46
10
0
% T
% Val:
0
0
10
0
0
10
10
0
0
0
10
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _